WebMar 27, 2024 · A variety of adipose depots were examined. Four articles detected high ACE-2 gene expression in adipose tissue relative to other tissue types (Table 1). The other four articles examined ACE-2 mRNA expression in relation to BMI . WebAngiopoietin-like 4 is a protein that in human is encoded by the ANGPTL4 gene. [5] [6] [7] Alternatively spliced transcript variants encoding different isoforms have been described. This gene was previously referred to as …

PLIN2 Gene - GeneCards PLIN2 Protein PLIN2 Antibody

WebMar 12, 2024 · Adipose tissue (AT) is an integral component of increased weight gain and has garnered significant attention in the scientific community over the last few decades. White and brown ATs (WAT and BAT), being the two main types of AT in mammals, are the focus of most scientific studies. WebNormal Function. The PNPLA2 gene provides instructions for making an enzyme called adipose triglyceride lipase (ATGL). The ATGL enzyme plays a role in breaking down fats called triglycerides, which are the main source of stored energy in cells. Triglycerides are the major component of cell structures called lipid droplets (also called adiposomes). iaff 1264

Obese gene expression at in vivo levels by fat pads derived from …

Adipocytes play a vital role in energy homeostasis and process the largest energy reserve as triglycerol in the body of animals. Adipocytes stay in a dynamic state, they start expanding when the energy intake is higher than the expenditure and undergo mobilization when the energy expenditure exceeds the intake. This process is highly regulated by counter regulatory hormones to which these cells are very sensitive. The hormone insulin promotes expansion whereas the co… The recent GWAS catalog of 71,423 records for 2,688 diseases or traits was used to select and classify 34 diseases or traits into four obesity-associated categories: obesity, type 2 diabetes, blood lipids, and inflammation (Supplementary Table 2). In order to identify obesity candidate genes among adipose … See more Prior to initiating our workflow (Fig. 1), the GTEx dataset was downloaded from the GTEx portal (www.gtexportal.org), and then adipose-specific genes under the … See more To obtain insight into roles of unreported adipose-specific genes in adipose tissue, functional annotations of the genes and information from literature describing their … See more DEGs between subcutaneous and omental adipose tissues were identified and then subjected to GWAS integration and KEGG pathway analyses to … See more Considering differential expression of some development-related genes between adipose depots, expression pattern of homeotic genes in subcutaneous and … See more WebJun 5, 2024 · Adipose tissue macrophages are a prominent source of pro-inflammatory cytokines including TNFα and IL-6, which can block insulin action [ 15, 16 ], causing IR. In obese mice, when inflammatory... molton brown advent 2022