WebApr 13, 2024 · Additional file 3: Figure S3. The impacts of CLK1 overexpression and knockdown on the migration and invasion of 8988 cells. (A-H) 8988 cells with stable CLK1 overexpression (A-D) and with CLK1 knockdown (E–H) were generated.Cell migration and invasion ability (A-C, E–G), and wound healing ability (D, H) in the indicated cell lines … WebFeb 3, 2024 · During stress recovery, CDC like kinase 1 (CLK1) was recruited to nSBs and accelerated the re-phosphorylation of SRSF9, thereby promoting target intron …
Inhibition of a Novel CLK1-THRAP3-PPARγ Axis Improves Insulin ...
WebNov 5, 2024 · Based on these data, we hypothesize that DYRK1A-mediated upregulation of CCND3 and MYC forces the cells to proliferate, which significantly increases replication … stream wrong turn 6
SRSF1 serine and arginine rich splicing factor 1 [ (human)]
WebJun 6, 2024 · CLK1 also auto-regulates AS of its own exon 4, of which the skipping generates a truncated and catalytically inactive protein isoform []. Notably, CLK1 intron 4 is variably retained and exon 4 largely excluded, also in a subset of human cancer cell lines and this regulation is reverted by stress conditions []. Thus, alteration of this conserved ... WebApr 1, 2024 · A phospho-specific peptide corresponding to residues surrounding Ser337 and Thr338 of human CLK1 (AA334-341) Immunogen Species : Human. Accession Number : NP_001155879. ... we offer a wide range of products for scientists in cancer, neuroscience, epigenetics, cell signalling, and cellular stress research areas. Based in Victoria, BC, … WebSep 5, 2024 · CLK1 intron 4 retention and exon 4 skipping rapidly diminish in conditions of severe cellular stress. • CLK1 inhibition with the benzothiazole TG003 results in an … rowlands auto care