WebMar 30, 2024 · A master organizer of genome architecture is the CCCTC-binding factor (CTCF), which is ubiquitously expressed across nearly all tissues. 6 CTCF blocks the adenosine triphosphate-dependent extrusion of chromatin by the cohesin complex, thereby stabilizing long-range chromatin contacts throughout the genome. 7 , 8 , 9 WebNov 26, 2012 · INTRODUCTION. The CCCTC-binding factor, CTCF, is a ubiquitously expressed transcriptional regulator protein that is highly conserved from fly to man (1, 2).It was first identified as a transcriptional repressor of the MYC oncogene (3, 4) and, subsequently, has been shown to be involved in an extraordinarily diverse set of …
Genomic coordinates of CTCF binding sites, with orientation
WebMay 4, 2024 · As described by Huang et al. , the potency of CTCF-mediated transcriptional insulation likely depends on several characteristics, including the number of tandem CTCF protein binding sites, DNA sequences surrounding the protein binding motifs, and the location of the CTCF protein binding sites (inside TAD boundaries is more likely to … WebAug 23, 2024 · Previous studies show that chromatin loops are mediated by architectural proteins CCCTC-binding factor (CTCF) and cohesin through extrusion, in which CTCF motif binds to a specific non-palindromic motif in a convergent orientation at two sites and acts as a loop anchor ( Fudenberg et al., 2016; Salameh et al., 2024; Sanborn et al., 2015 ). birmingham silver company silver on copper
IJMS Free Full-Text The Chromatin Architectural Protein CTCF Is ...
WebWe noticed that multiple CTCF-binding sites are present in the BCL11B enhancer region that are complementary (convergent) to those found in the transcriptional regulatory … WebFeb 27, 2024 · CCCTC-binding factor (CTCF) is a highly conserved, ubiquitously expressed zinc finger protein. CTCF is a multifunctional protein, associated with a number of vital cellular processes such as... WebJun 5, 2024 · CCCTC-binding factor (CTCF), a zinc finger DNA-binding protein, is largely responsible for bridging this gap between expression and chromatin organization. CTCF functions in gene transcription and repression and as an insulator that interferes with enhancer-promoter interactions [ 4, 5 ]. dangerous touch full movie