Mtor hif ucp2
Web持续高血糖可促进缺氧诱导因子-1α(hif-1α)表达，增强肿瘤细胞的抗凋亡能力[11]。hif-1α促进hcc发展，在hcc中抑制hif-1α活性，可抑制肿瘤血管生成，促进肝癌细胞凋亡[12]。lin等[13]研究证实，高血糖能够显著诱导活性氧(ros)的产生，引发小鼠脂肪组织的炎性反应 ... Web2 aug. 2024 · HIF-1α directly bound vascular endothelial growth factor A (Vegfa) and …
Mtor hif ucp2
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WebHoeffer CA, Klann E (2010) mTOR signaling: at the crossroads of plasticity, memory and disease. Trends Neurosci. 33(2), 67–75. Laplante M, Sabatini DM (2013) Regulation of mTORC1 and its impact on gene expression at a glance. J. Cell. Sci. 126(Pt 8), 1713–9. Laplante M, Sabatini DM (2012) mTOR signaling in growth control and disease. Web1 nov. 2024 · This is caused by the toll like receptor (TLR)-induced expression of HIF-1α, leading to enhanced production of lactate from pyruvate (Imtiyaz and Simon, 2010, Kim et al., 2006). Overexpression of UCP2 was shown to reduce intracellular ROS levels and macrophages' adhesion downregulating β2 integrin expression (Je-Won, 2004).
WebAna I. Duarte, ... Mariusz R. Wieckowski, in Aging, 2024 8.6.1.5.2 UCP2, UCP3 and UCP4. UCP2 is ubiquitously expressed throughout the body, including the brain and pancreatic β-cells. 369 Though Dietrich and Horvath hypothesized that UCP2 could be a pivotal player in regulating lifespan and senescence, 428 studies performed in mice with upregulation or … Web1. UCP2 mRNA is found in many tissues (9) whereas UCP1, UCP3, UCP4, and BMCP1 …
Web(n = 9 in each group). c, Immunoblot analysis of 3F-UCP2 B16-OVA cell and dual … http://www.ebiotrade.com/newsf/2024-9/202493154829564.htm
Web15 iun. 2013 · Summary. The asparaginyl hydroxylase factor inhibiting HIF-1 (FIH-1) is an important suppressor of hypoxia-inducible factor (HIF) activity. In addition to HIF-α, FIH-1 was previously shown to hydroxylate other substrates within a highly conserved protein interaction domain, termed the ankyrin repeat domain (ARD). However, to date, the …
WebHere, we demonstrate that inhibition of UCP2 triggers Akt/mTOR pathway in a ROS … trey borzillieriWeb12 mar. 2024 · The aim of the present study was to characterize the expression of uncoupling protein 2 (UCP2) in melanoma and to study the potential mechanisms underlying the involvement of UCP2 in melanomagenesis using human melanoma cell lines. The expression of UCP2 was evaluated in specimens from normal control subjects, patients … tenna shoe storestreyborne coveWeb14 iul. 2014 · Moreover, UCP2 overexpression is associated with an activation of adenosine monophosphate-activated protein kinase (AMPK) signaling together with a downregulation of hypoxia-induced factor (HIF) expression. Finally, UCP2 overexpression can amplify apoptosis induced by chemotherapeutic drugs, such as staurosporine. trey bowlesWeb1 nov. 2024 · This is caused by the toll like receptor (TLR)-induced expression of HIF-1α, … trey boyerWeb31 aug. 2016 · HIF-1α是目前发现的唯一一个特异性缺氧状态下发挥活性的转录因子，广泛存在于哺乳动物细胞中，其参与了多条细胞信号通路，是介导缺氧信号的转导中枢。. 研究发现，HIF-1α在动物心血管系统的生成、软骨系统的发育和神经胚的形成过程中都有表达，可以 … trey bowen insurance agentWeb6 aug. 2024 · The master transcription factors HIF-1 and HIF-2α are critical effectors in this metabolic shift and are stabilized by hypoxic, inflammatory, ... UCP2-deficient endothelial cells exhibited increased mitophagy and reduced mitochondrial mass . More work is required to understand how UCP2 and other factors may interconnect processes of biogenesis ... trey bowden andy griffith