Otud6a topbp1

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August undefined, 2024

WebOTUD6A is part of cluster 11 Basophils - Unknown function with confidence i 0.61 166 genes in cluster Go to interactive expression cluster page. 15 nearest neighbours based on … WebMar 19, 2015 · Human TopBP1 plays essential roles in DNA replication and replication checkpoint control. In our recent paper “TopBP1 controls BLM protein level to maintain genome stability,” we provided evidence suggesting that TopBP1 has an unexpected role in suppressing sister chromatid exchange (SCE) and that this function is independent of its …

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WebMay 18, 2010 · Function. Required for DNA replication. Plays a role in the rescue of stalled replication forks and checkpoint control. Binds double-stranded DNA breaks and nicks as … WebFeb 25, 2024 · These results indicate that OTUD6A is a physiological DUB for c-Myc in PrCa setting and ... Deubiquitinase OTUD6A promotes breast cancer progression by increasing … botanical remedy dispensary tulsa

Prostate-specific oncogene OTUD6A promotes prostatic …

WebJul 14, 2024 · 进一步研究发现，敲低去泛素化酶otud6a ，能使细胞阻滞在s期，导致chk1激活受阻，并使得基因组不稳定性提高，进而增加肿瘤细胞对化疗药物的敏感性。裸鼠成瘤实验也表明，otud6a的敲低通过负调控topbp1蛋白水平，抑制了乳腺癌肿瘤的生长。 Web该研究发现otud6a通过调控topbp1蛋白的泛素化修饰和稳定性来参与dna损伤修复，维持细胞基因组稳定性，抑制肿瘤细胞对放化疗药物的敏感性并促进乳腺癌的发展。揭示了去泛素化酶otud6a参与dna损伤应答及调控肿瘤细胞耐药的分子机制。 WebSubsequently, OTUD6A was recruited to the damage site, where it interacted with TopBP1 and blocked the interaction between TopBP1 and its ubiquitin E3 ligase UBR5, decreasing … botanical repair

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Deubiquitinase OTUD6A Promotes Breast Cancer Progression

WebATM TOPBP1. Biochemical Activity. Biochemical Activity. An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. WebMar 21, 2024 · TOPBP1 (DNA Topoisomerase II Binding Protein 1) is a Protein Coding gene. Diseases associated with TOPBP1 include Ataxia-Telangiectasia and Seckel Syndrome.Among its related pathways are Homologous DNA Pairing and Strand Exchange and Homology Directed Repair.Gene Ontology (GO) annotations related to this gene … botanical removable wallpaperWebJun 29, 2024 · Subsequently, OTUD6A was recruited to the damage site, where it interacted with TopBP1 and blocked the interaction between TopBP1 and its ubiquitin E3 ligase … haworth meeting point

"WebFeb 15, 2024 · Gene Summary. Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in protein deubiquitination. Orthologous to human OTUD6A (OTU deubiquitinase 6A) and OTUD6B (OTU deubiquitinase 6B). (Alliance, FBgn0026738 ) Contribute a Gene Snapshot for this gene. " - Otud6a topbp1

Otud6a topbp1

TopBP1 in X-irradiation-induced DNA damage response. A

WebSep 9, 2024 · Cytokinin plays critical roles in root development. Cytokinin signaling depends on activation of key transcription factors known as type B Arabidopsis response … WebJul 12, 2024 · Subsequently, OTUD6A was recruited to the damage site, where it interacted with TopBP1 and blocked the interaction between TopBP1 and its ubiquitin E3 ligase …

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WebTopBP1 also regulates initiation of DNA replication along with the DNA replication factor treslin (6,7). TopBP1 has been shown to prevent replication associated DNA damage during neurogenesis (8), and to interact with mutant p53, mediating mutant p53 gain-of-function activity such as growth promotion and resistance to chemotherapeutic drugs (9). WebShowing of 852 Results for OTUD6A Search Time: 0 ms. Export Show: Symbol Description Category UniProt ID GIFtS GC id Score; 1: ... TOPBP1: DNA Topoisomerase II Binding …

WebFeb 7, 2024 · Title: Deubiquitinase OTUD6A promotes breast cancer progression by increasing TopBP1 stability and rendering tumor cells resistant to DNA-damaging therapy. … WebJun 29, 2024 · Subsequently, OTUD6A was recruited to the damage site, where it interacted with TopBP1 and blocked the interaction between TopBP1 and its ubiquitin E3 ligase …

WebThe Input lane is 10% input; the TOPBP1-IP lane is the immunoprecipitation with the TOPBP1 antibody (2.5 µg, VMA00940); the IgG-IP lane is the immunoprecipitation with … Web1 day ago · Deubiquitinase OTUD6A promotes breast cancer progression by increasing TopBP1 stability and rendering tumor cells resistant to DNA-damaging therapy 相关领域

WebDeubiquitinase OTUD6A promotes breast cancer progression by increasing TopBP1 stability and rendering tumor cells resistant to DNA-damaging therapy. Yan Zhao; Xinping Huang; …

WebShowing of 852 Results for OTUD6A Search Time: 0 ms. Export Show: Symbol Description Category UniProt ID GIFtS GC id Score; 1: ... TOPBP1: DNA Topoisomerase II Binding Protein 1: Protein Coding: Q92547: 48: GC03M133600: 1.64: 22: UBR5: Ubiquitin Protein Ligase E3 Component N-Recognin 5: Protein Coding: O95071: 47: botanical remediesWebJun 29, 2024 · Deubiquitinase OTUD6A promotes breast cancer progression by increasing TopBP1 stability and rendering tumor cells resistant to DNA-damaging therapy. Sign in … haworth men\\u0027s clothingWebJan 8, 2024 · Deubiquitinase OTUD6A promotes breast cancer progression by increasing TopBP1 stability and rendering tumor cells resistant to DNA-damaging therapy. … haworth medical pressWebDetection of human TopBP1 by western blot. Samples: Whole cell lysate (15 µg) from HeLa, 293T, and Jurkat cells prepared using NETN lysis buffer.Antibody: Affinity purified rabbit … haworth mens jumpers haworth medical practice modalityWebOTUD6A is upregulated in human patients with colorectal cancer. The depletion of OTUD6A leads to lower Drp1 levels and suppressed mitochondrial fission, and the affected cells are consequently less prone to tumorigenesis. Conversely, the overexpression of OTUD6A increases Drp1 levels and its protein half-life and enhances cancer cell growth. botanical remedies kratomWebJun 30, 2024 · Deubiquitinase OTUD6A Promotes Breast Cancer Progression by Increasing TopBP1 Stability and Rendering Tumor Cells Resistant to DNA-Damaging Therapy. … haworth merchandise mart