Phosphatase tensin-type domain
WebMar 28, 2024 · Among them, Src homology region 2 domain containing phosphatase-1 (SHP1), phosphatase and tensin homolog deleted on chromosome 10 (PTEN), and MAP kinase phosphatase 1 (MKP1) act as negative regulators in OCs. SHP1 is a non-receptor-type PTP, which is a product of Ptpn6. WebContains 1 phosphatase tensin-type domain. 结构域 The C2 domain binds phospholipid membranes in vitro in a Ca(2+)-independent manner; this binding is important for its tumor suppressor function.
Phosphatase tensin-type domain
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WebPhosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchanger factor 2 (PREX2) is a novel regulator of the small guanosine triphosphatase Rac, and has been observed to be implicated in human cancer by inhibiting the activity of phosphatase and tensin homolog (PTEN), thus upregulating the activity of the phosphoinositide 3-kinase (PI3K) signaling … WebProteins known to contain a phosphatase and a C2 tensin-type domain are listed below: Tensin, a focal-adhesion molecule that binds to actin filaments. It may be involved in cell …
WebSMART: PTEN_C2 domain annotation PTEN_C2 C2 domain of PTEN tumour-suppressor protein There are 6056 PTEN_C2 domains in 6045 proteins in SMART's nrdb database. Click on the following links for more information. Evolution (species in which this domain is found) Cellular role (predicted cellular role) Structure (3D structures containing this domain) WebNov 4, 2024 · Also known as ATPEN2; phosphatase and TENsin homolog deleted on chromosome ten 2A; PTEN 2; PTEN2A Summary Encodes a phosphatase with low in vitro tyrosine phosphatase activity that is capable of dephosphorylating in vitro the 3'phosphate group of PI3P, PI (3,4)P2, and PI (3,5)P2 and may be an effector of lipid signaling. NEW …
WebKey features and details Rabbit polyclonal to PTEN Suitable for: IHC-P, WB Reacts with: Human Isotype: IgG Get better batch-to-batch reproducibility with a recombinant antibody Anti-PTEN antibody [EPR9941-2] (ab170941) Research with confidence – consistent and reproducible results with every batch WebEnables lipid phosphatase activity. Acts upstream of or within several processes, including lifelong otolith mineralization; negative regulation of angiogenesis; and phosphatidylinositol dephosphorylation. Predicted to be located in PML body and cytoplasm.
WebDescription: Homo sapiens transmembrane phosphatase with tensin homology (TPTE), transcript variant 1, mRNA. (from RefSeq NM_199261) RefSeq Summary (NM_199261): …
WebJan 2, 2024 · Phosphatase and tensin homolog deleted on chromosome 10 ( PTEN ) encodes a 403-amino acid protein with an amino-terminal domain that shares sequence … passiflora incarnata flower eWebPhosphatase and tensin homolog (PTEN) is a tumor suppressor and component of PI3K-AKT-mTOR signaling. Cowden syndrome is an inherited, autosomal dominant phenotype composed of multiple hamartomas typically found in the skin, mucous membranes including the gastrointestinal tract, thyroid, and breast. お札 グラムPhosphatase and tensin homolog (PTEN) is a phosphatase in humans and is encoded by the PTEN gene. Mutations of this gene are a step in the development of many cancers, specifically glioblastoma, lung cancer, breast cancer, and prostate cancer. Genes corresponding to PTEN (orthologs) have been … See more PTEN protein acts as a phosphatase to dephosphorylate phosphatidylinositol (3,4,5)-trisphosphate (PtdIns (3,4,5)P3 or PIP3). PTEN specifically catalyses the dephosphorylation of the 3` phosphate of the See more The structure of the core of PTEN (solved by X-ray crystallography, see figure to the upper right ) reveals that it consists primarily of a phosphatase domain, and a C2 domain: the phosphatase domain contains the active site, which carries out the See more PTEN inhibitors Bisperoxovanadium compounds may have a neuroprotective effect after CNS injury. PTEN is inhibited by See more PTEN (gene) has been shown to interact with: • CSNK2A2, • CSNK2A1, • MAGI3 • MVP, • NEDD4, See more Cancer PTEN is one of the most commonly lost tumor suppressors in human cancer; in fact, up to 70% of men with prostate cancer are estimated to have lost a copy of the PTEN gene at the time of diagnosis. A number of studies … See more Cell lines with known PTEN mutations include: • prostate: LNCaP, PC-3 • kidney: 786-O • glioblastoma: U87MG • breast : MB-MDA-468, BT549 See more • Multiple hamartoma syndrome See more passiflora incarnata floridaWebMar 21, 2024 · TNS3 (Tensin 3) is a Protein Coding gene. Diseases associated with TNS3 include Thyroid Tumor and Primary Syphilis . Among its related pathways are MET promotes cell motility and Signaling by Receptor Tyrosine Kinases . Gene Ontology (GO) annotations related to this gene include phosphatase activity . An important paralog of this gene is … お札 クリアファイルWebGene Variant Descriptions. PTEN D24H lies within the phosphatase tensin-type domain of the Pten protein (UniProt.org). D24H results in reduced phosphatase activity in a yeast assay ( PMID: 29706350 ), and results in abnormal cellular localization and loss of PI3K/AKT/MTOR pathway inhibition, as indicated by increased expression of S6rp in ... passiflora incarnata growing zoneWebPTEN H93Y lies within the phosphatase tensin-type domain of the Pten protein (UniProt.org). H93Y demonstrates loss of phosphatase activity ( PMID: 10866302 , PMID: … お札 クリアファイル 神棚WebApr 3, 2024 · PTEN phosphatase and tensin homolog Gene ID: 5728, updated on 3-Apr-2024 Gene type: protein coding Also known as: BZS; DEC; CWS1; GLM2; MHAM; TEP1; MMAC1; … お札 クリアファイル 100均