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Phosphopantetheine binding acp domain

The acyl carrier protein (ACP) is a cofactor of both fatty acid and polyketide biosynthesis machinery. It is one of the most abundant proteins in cells of E. coli. In both cases, the growing chain is bound to the ACP via a thioester derived from the distal thiol of a 4'-phosphopantetheine moiety. WebPhosphopantetheine, also known as 4'-phosphopantetheine, is a prosthetic group of several acyl carrier proteins including the acyl carrier proteins (ACP) of fatty acid synthases, ACPs of polyketide synthases, the peptidyl carrier proteins (PCP), as well as aryl carrier proteins (ArCP) of nonribosomal peptide synthetases (NRPS). [1]

Structural and binding studies of phosphopantetheine …

WebPhosphopantetheine transferases (PPTases) from E. coli (AcpS) and Bacillus subtilis (Sfp) have been used for the enzyme-mediated protein labeling system ( Fig. 5A ). 143 PPTases catalytically transfer 4′-phosphopantetheine from coenzyme A (CoA) to the serine residue of an acyl carrier protein (ACP) or peptidyl carrier protein (PCP). WebMar 1, 2002 · Furthermore, the helical structure of ACP resembles that of 14-3-3, which suggests that this region of the enzyme may be important in ACP recognition and binding. Therefore, it is likely that the AHL synthase binds acyl-ACP first, followed by a conformational rearrangement of the N-terminal domain and SAM binding in a bi-ter … dan simmons right wing https://asloutdoorstore.com

PDB 2kr5 structure summary ‹ Protein Data Bank in Europe (PDBe) …

WebPhosphopantetheine adenylyltransferase (PPAT, EC. 2.7.7.3) catalyzes an essential step in the reaction that transfers an adenylyl group from adenosine tri phosphate (ATP) to 4' … Phosphopantetheine, also known as 4'-phosphopantetheine, is a prosthetic group of several acyl carrier proteins including the acyl carrier proteins (ACP) of fatty acid synthases, ACPs of polyketide synthases, the peptidyl carrier proteins (PCP), as well as aryl carrier proteins (ArCP) of nonribosomal peptide synthetases (NRPS). It is also present in formyltetrahydrofolate dehydrogenase. WebJul 31, 2014 · (1) Movement of the ACP’s phosphopantetheine (Ppant) arm is thought to be coordinated with protein–protein interactions and significant rearrangement of the PKS enzyme assembly. (2-5) The dynamic structures of ACPs and their Ppant arms are difficult to track due to the flexibility of ACPs and ACPs’ transient interactions with catalytic … birthday poem from the dog

CDD Conserved Protein Domain Family: PP-binding - National …

Category:protein coding gene - lys1 (SPAP7G5.04c) - PomBase

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Phosphopantetheine binding acp domain

SMART: PKS_PP domain annotation

WebNov 13, 2013 · 4ihh: Chasing acyl carrier protein through a catalytic cycle of lipid A production.

Phosphopantetheine binding acp domain

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WebSep 5, 2008 · FAS inhibitors have demonstrated anti-tumor activity in vivo and in vitro, and in recent years FAS has emerged as an important drug target for the treatment of human … WebThis multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ( [ACP]) domain. Catalytic activity acetyl-CoA + 2n H+ + n malonyl-CoA + 2n NADPH = a long-chain fatty acid + n CO2 + (n+1) CoA + 2n NADP+ 3 publications

WebPhosphopantetheine-binding site.: (A) Structural superposition of ATP-bound MsFadD32 and adenylate analog- and phosphopantetheine-bound PA1221 protein. The N- and C … WebMar 2, 2010 · Phosphopantetheine binding ACP domain Structure analysis Details Assembly composition: monomeric ( preferred) Entry contents: 1 distinct polypeptide molecule Macromolecule: Norsolorinic acid synthase Molecule details › Chain: A Length: 89 amino acids Theoretical weight: 9.43 KDa Source organism: Aspergillus parasiticus

WebNov 20, 2024 · Fatty acid and phospholipid metabolism Other PAO1 genes in this class Pathways Functional Predictions from Interpro Search for additional functional domains at the NCBI CDD database website. Go to this protein's … WebJul 5, 2024 · Sequence domains: Thioester reductase-like domain; ACP-like superfamily; Phosphopantetheine binding ACP domain; AMP-dependent synthetase/ligase domain; …

WebFeb 16, 2016 · The selection of the starter unit is generally governed by the substrate specificity of the AT domain in the loading module ().In some modular PKS systems, a didomain-type loading module comprising a loading AT domain and an ACP domain selects an acyl starter building block such as an acetate unit to generate an acyl–ACP …

WebJul 31, 2014 · (1) Movement of the ACP’s phosphopantetheine (Ppant) arm is thought to be coordinated with protein–protein interactions and significant rearrangement of the PKS … dan simmons net worthWebJul 21, 2024 · The phosphopantetheine-binding domain (PP-binding superfamily), conserved in ACP proteins, is the prosthetic group of ACP, which acts as a linker for the attachment of the activated FA and amino acid groups via a phosphodiester bond (Crawford et al. 2008; Meier et al. 2010; ... dan simmons newsWebJan 12, 2024 · Phosphopantetheine binding ACP domain (Q24722578) InterPro Domain PP-bd_ACP IPR009081 edit Statements instance of protein domain 1 reference subclass of … dan simmons law firmWebJul 22, 2015 · Acyl carrier protein (ACP) Phosphopantetheine binding ACP domain; Structure analysis Details. Assembly composition: monomeric . Entry contents: 1 distinct polypeptide molecule ... Sequence domains: Phosphopantetheine attachment site. Ligands and Environments No bound ligands. No modified residues. dan simmons next bookWebChr: 1 Mapping Details/Browsers Description Predicted to enable acyl binding activity and acyl carrier activity. Predicted to act upstream of or within fatty acid biosynthetic process. … dan simmons seasons of horror seriesWebNov 20, 2024 · Phosphopantetheine binding ACP domain 2710 2771 2.6E-13 SUPERFAMILY SSF52777 CoA-dependent acyltransferases -- 3253 3430 2.22E-46 Pfam PF13193 AMP … birthday poems by famous authorsWebJun 2, 2011 · Introduction. One of the most distinctive features of fatty acid, nonribosomal peptide and polyketide biosynthetic pathways is the utilization of the acyl carrier protein (ACP) or peptidyl carrier protein (PCP) for the shuttling of biosynthetic intermediates among various catalytic domains or proteins –.The small and highly dynamic ACPs or PCPs can … dan simmons hyperion cantos