WebJul 11, 2011 · One possible explanation for this observation is a role for DXR/p53 signaling to stabilize SHP proteins. Of note, it has been shown that SHP proteins are rapidly degraded in hepatocytes and that bile acids and bile acid-induced FGF19 signaling pathways increase SHP stability by inhibiting its ubiquitination and proteasomal degradation ( 27 ). WebBile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c. We explored the effects of bile acids on triglyceride (TG) homeostasis using a combination of molecular, cellular, and animal models. Cholic acid (CA) prevents hepatic TG accumulation, VLDL secretion, and elevated serum TG in mouse models of ...
Bile acids lower triglyceride levels via a pathway involving …
WebFeb 7, 2024 · SHP is transcriptionally induced by the bile acid nuclear receptor FXR (farnesoid X receptor) after feeding, but SHP protein stability and its gene repression activity are also increased... WebFeb 17, 2014 · Abstract The nuclear bile acid receptor farnesoid X receptor (FXR) is an important transcriptional regulator of bile acid, lipid, and glucose metabolism. FXR is highly expressed in the liver and intestine and controls the … sws motorsports
Dynamics of the enterohepatic circulation of bile acids in healthy ...
WebJan 25, 2024 · Bile acids (BAs) are synthesized from cholesterol, produced in the hepatocytes, stored in the gallbladder, and secreted into the intestine to facilitate the digestion of lipids and the absorption of triglycerides (TG), cholesterol, and lipid-soluble vitamins ( 7, 8 ). WebJun 29, 2024 · Regulation of bile acid metabolism is normally discussed as the regulation of bile acid synthesis, which serves to compensate for intestinal loss in order to maintain a constant pool size. After a meal, bile acids start cycling in the enterohepatic circulation. Farnesoid X receptor-dependent ileal and hepatic processes lead to negative feedback … WebJul 8, 2024 · In humans, the primary bile acids cholic acid (CA) and chenodeoxycholic acid (CDCA) are synthesized in the liver and can be converted by intestinal bacteria into secondary deoxycholic (DCA) and lithocholic (LCA) acids and a number of less abundant metabolites, which can all be re-absorbed from the intestine (see Fig. 1 and the next … sws motors